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PYY is a peptide released from colonic EECs in response to nutrients, with PYY3-36 being the most prevalent form of this gut peptide in the circulation 198,199
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IGF-1 LR3 has an extended activity window of roughly 20 to 30 hours versus the minutes-long half-life of native IGF-1, making it potently anabolic in animal models but carrying hypoglycemia and oncogenic risk in humans
